Nanoscale‐alumina induced cognitive dysfunction in mice related to hippocampal structural changes: A stereological study

Background Aluminum (Al) is known to induce neurotoxicity in both humans and rodents. Recent evidence has indicated that the toxicity of Al Oxide (Al2O3) Nanoparticles (Al-NP), one most abundantly used engineered nanoparticles, far greater than itself. To date, however, no information available regarding effect Al-NP on stereological parameters hippocampus. In particular, studies have evaluated hippocampal CA1, dentate gyrus volume, number pyramidal granular cells. Method Adult male NMRI mice were treated with AlNP dose 10 mg/kg/oral gavage for 5 days. The test session novel object recognition (NOR) task was performed day 5. Following NOR test, hippocampi analyzed apoptotic. Result results demonstrated five-day ingestion elicited a reduced preference explore (a hippocampal-dependent task). Perhaps contributing this memory deficit, induced additional alterations hippocampus terms (1) volume (decreased whole hippocampus, regions), (2) cell CA1 neurons cells), (3) increased cleaved caspase-3 Conclusion These provided new mechanistic insight understand impairing AL-NP function structure.